Spindled component may be positive for high molecular weight keratin or p63. Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation. Treatment can be either wide local excision or mastectomy to achieve histologically clear margins. The median age is 45 years, ranges from 10 to 86 and it is uncommon to occur in. This type of tumor is called a sarcoma, because it occurs in the connective tissue stroma of your breast, rather than in epithelial tissue lining of ducts and lobes. Once i got surgery it came back as a phyllodes tumor that was benign. Last month i had a partial mastectomy for a highgrade malignant phyllodes tumor. Surgery is the main treatment for phyllodes tumors of the breast. Phyllodes tumor benign or malignant, phylloides tumor, phyllodes tumour, phylloides tumour, mullers tumor, cystosarcoma phyllodes, phyllodes, pt, and csp. Overlying skin may display a shiny appearance and be translucent enough to reveal underlying breast veins. Women with lifraumeni syndrome a rare, inherited genetic. The phyllodes tumor has a lobulated, leaflike appearance and varies in size from 1 cm to greater than 15 cm.
Jul 04, 2016 surgery is the main treatment for phyllodes tumors of the breast. Phyllodes tumors of the breast are rare fibroepithelial lesions that comprise less than 1% of all breast malignancies. Changes in the clinical characteristics, treatment options, and therapy outcomes in patients with phyllodes tumor of the breast during 55 years of experience. Phyllodes tumours are rare fibroepithelial lesions. When a phyllodes tumor is clinically suspected, mammograms and ultrasound evaluation are advised, although the imaging studies may. Originally described in 1838 by muller, phyllodes tumor is a rare fibroepithelial neoplasm. This includes the tissue and ligaments that surround the ducts. Analisis ekspresi cd117 dan ki67 pada tumor phyllodes benign majalah patologi fetty fatimah, sjahjenny mustokoweni, alphania rahniayu vol. May have benign adipose tissue as primary stromal component lipophyllodes tumor, arch pathol lab med 1994. Phyllodes tumor is a very rare type of breast tumor, which can be benign harmless or malignant cancerous. Phyllodes tumors are often large, bulky, fast growing masses that form from the intralobular stroma of the breast. Phyllodes tumors are rare breast tumors that start in the connective tissue and are most common in women in their 30s and 40s. Adverse features stromal overgrowth one 40x field without epithelium high mitotic index 10 10 hpf.
Grading staging report phyllodes tumor of the breast. The stroma is markedly cellular and the stromal cells show marked nuclear pleomorphism. Phyllodes tumor of the breast genetic and rare diseases. Jul 07, 2018 scribd is the worlds largest social reading and publishing site. A very large phyllodes tumor may erode through overlying skin and present as an external fungating breast mass. Here are links to possibly useful sources of information about phyllodes tumor. Ideal sources for wikipedia s health content are defined in the guideline wikipedia. Malignant phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Stromal component negative for high molecular weight keratin and p63. Kanker payudara kpd merupakan keganasan pada jaringan payudara. So theyre a little different from the other benign breast conditions linked to a. Phyllodes tumors grow in the connective tissue of the breast, called the stroma. Some doctors feel that an even wider margin of healthy tissue should be removed.
Phyllodes tumor is a rare, malignant growth of the breast cancer that develops rapidly. In rare cases, a benign tumor can recur grow back as a cancer. We present a case of a 33yearold woman affected by. Phyllodes tumours are rare and are usually benign not cancer. If the phyllodes tumor of the breast is benign or borderline histology, radiation therapy.
Malignant phyllodes tumor of the breast with metastasis to the. The most common site of phyllodes tumor is the breast in general, phyllodes tumor may be classified as benign, malignant, or borderline tumor based on their behavior. They are graded as benign, borderline or malignant based on the world health organisation who classification, according to a constellation. Statistics of phyllodes tumor 39 people with phyllodes tumor have taken the sf36 survey. Its name is derived from the greek words sarcoma fleshy tumor, and phyllon leaf. Phyllodes tumors are most common in women in their 40s, but women of any age can have them. Missed diagnoses of phyllodes tumor on breast biopsy. Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. Characterized by a combination of hyper cellular stroma and cleftlike spaces lined by epithelium, phyllodes tumor was classically known as cystosarcoma phyllodes because of the leaflike projections. The remaining 3 patients were preoperatively diagnosed with core needle biopsy. Phyllodes tumors of the breast american cancer society. Jan 22, 2020 the most common symptom of a phyllodes tumor is a painless breast lump that you or your doctor can feel while examining the breasts. The clinical presentation of this tumor is unilateral, and the behavior and.
The tumor is rarely found in adolescents and the elderly. Current trends in the management of phyllodes tumors of. Phyllodes tumors are rare fibroepithelial neoplasms that account for 0. Nov 05, 2018 malignant phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Borderline and malignant phyllodes tumours breast cancer now. Cystosarcoma phyllodes arising synchronously in right breast and bilateral axillary. Phyllodes tumors account for less than 1% of all breast cancers.
Differential diagnosis phyllodes tumor of the breast. They are graded as benign, borderline or malignant based on the world health organisation who classification, according to a constellation of 5. Radiation oncologybreastphyllodes wikibooks, open books. Because these tumors can come back if enough normal tissue is not removed, surgery should involve removing the tumor and at least 1 cm of the surrounding tissue. A 40 yearold white woman presented with threeweek history of pain and functional impairment of the left lower limb. It doesnt hurt to get a second look becuase regardless if its benign or melignant it seems like its just the same procedures done. Cystosarcoma phyllodes is a rare, predominantly benign tumor of the breast. The exact aetiology of phyllodes tumour and its relationship with fibroadenoma are unclear.
Aggressive malignant phyllodes tumor sciencedirect. Request pdf malignant phyllodes tumor of the breast. Malignant phyllodes tumour with metastasis to the lung. They account for less than 1% of all breast neoplasms. Since phyllodes tumors are locally recurrent tumor especially when not excised with a clear margins and very u n p r e d i c t a b l ei ng r o w t ha n dm e t a s t a t i ca c t i v i t y,i ti sv. However, seeing as up to 70% of phyllodes tumors are benign, cystosarcoma was removed, and the tumor is now recognized simply as phyllodes tumor. It occurs in females in the third and fourth decades. A low magnification of the primary breast phyllodes tumour with a cystic space into which stromal fronds projected. Current trends in the management of phyllodes tumors of the. My pathology report showed that the tumor what removed entirely but, in certain sections, they were unable to determine whether the thin band of fibrous tissue abuts the surgical resection margin. May 11, 2017 a phyllodes tumor is a rare tumor of the breast.
However, in the setting where additional recurrence would create significant. Phyllodes comprehensive disease information in a quick reference format. If you have problems viewing pdf files, download the latest version of adobe reader. Analyses of patient, pathologic, and treatment characteristics were performed using univariate and multivariate cox regression analyses for the css endpoint. Other names for these tumors are phylloides tumor and cystosarcoma phyllodes. Curiously, phyllodes tumors tend to involve the left breast more commonly than the right. No single feature is reliable to predict clinical behavior of phyllodes tumors.
Borderline phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. This is the case regardless of whether they are benign or malignant. My doctor put both a fiberdinoma and phyllodes tumor down on the table for me because i was 19, diagnosed on sept 2012. Phyllodes tumors follow up care by jonas wilson, ing. Apr 29, 2011 phyllodes tumors are uncommon and unpredictable.
Phyllodes tumors tend to grow quickly, but they rarely spread. Diagnosing phyllodes tumors usually involves a combination of steps, such as a physical exam, a mammogram, and a biopsy. Menurut samsuhidajat 2004, tumor jinak payudara terdiri dari. Phyllodes tumors are uncommon and unpredictable mayo. Phyllodes tumors appear very similar to a benign lump known as a fibroadenoma. While managing a giant phyllodes tumor, emphasis should be on complete extirpation of all visible tumors and breast tissue during mastectomy to minimize the chances of recurrence.
A phyllodes tumor of the breast is a rare fibroepithelial tumor, accounting for 0. Bone metastasis from malignant phyllodes breast tumor. Phyllodes tumor page 1 of 4 md anderson cancer center. The term cystosarcoma phyllodes was coined by johannes muller in 1838 to describe the gross appearance of this cystic, fleshy, leafy, tumor of the breast, which he clearly stated to be a benign tumor. They usually occur in middleaged to elderly women but can occur at any age. However, some phyllodes tumours are malignant cancer. Phyllodes tumors johns hopkins kimmel cancer center.
In case of phyllodes growths, however, the classification is entirely different. A phyllodes tumour is a growth of cells that forms a hard lump in the breast. Phyllodes tumors fillodes or fullohdeez can also be spelled phylloides tumors fulloydeez. Fibroadenoma mammae adalah tumor jinak pada payudara perempuan. For language access assistance, contact the ncats public information officer. Lymph node involvement is rarely described in phyllodes tumors. Based on whether or not they are cancerous, these growths are distinguished into. These 3 patients were treated with a wide excision of the phyllodes tumor with at. My oncologist said its up to me if i want radiation, since its only recently being used more frequently for this type of cancer. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. The most common symptom of a phyllodes tumor is a painless breast lump that you or your doctor can feel while examining the breasts. Analysis of phyllodes tumor recurrence according to the. Ekspresi cd117 dan ki67 pada benign, borderline dan.
Phyllodes tumours pts of the breast are uncommon fibroepithelial neoplasms, comprising 0. Pdf 11 212tumor phyllodes jurnal rinaldi zainuddin. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. The malignant variant of phyllodes tumor is even lower. The value of fnac in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive. Scribd is the worlds largest social reading and publishing site. Phyllodes tumors pts, which are rare and mostly benign in nature, are fibroepithelial tumors of the breasts. They account for less than 1% of all breast tumors and display a wide range of biological behaviors, ranging from benign to highly aggressive. Mengenal fibroadenoma mammae tumor jinak pada payudara. Name l define l risk l detect l treatment l stagegrade l followup l metsrecur l link.
Mar 20, 20 depending on the size of the breast and the location of the phyllodes tumor, mastectomy may also be required for tumors that are between 5 and 10 cm in diameter. If the phyllodes tumor of the breast is benign or borderline histology, radiation therapy not routinely recommended after excision. Microscopically, the branching, hyperplastic ducts are surrounded by a stroma, which is mostly fibrous and much more cellular than fibroadenoma. Read further to know more about the causes, symptoms, diagnosis and treatment of this cancerous condition. Case presentation phyllodes tumor linkedin slideshare. It is typically a large, fast growing mass that forms from the periductal stroma of the breast. Jul 23, 2019 curiously, phyllodes tumors tend to involve the left breast more commonly than the right. Local recurrence of phyllodes tumor pt of the breast is an adverse outcome that can result in sarcomatous degeneration. Phyllodes tumor pt is uncommon neoplasm of breast, accounting for 0. Phyllodes tumors are rare solid lumps that usually present as a mass found during a womans breast selfexamination or on a routine physical examination. Phyllodes tumor is an extremely rare tumor of the breast.
Grossly, the tumor displays characteristics of a large, malignant sarcoma, takes on a leaflike appearance when sectioned, and displays epithelial, cystlike spaces when viewed histologically. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The trip database provides clinical publications about evidence. The term phyllodes tumor, which was previously known as cystosarcoma phyllodes, refers to a group of lesions with varying metastatic potential.
Learn more about the symptoms and diagnosis of phyllodes tumors. Meskipun biasanya jinak, beberapa tumor phyllodes dapat menjadi. It is usually present as solitary unilateral tumor in one breast or rarely multifocal in or both breasts. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported. Total score ranges from 0 to 3,600 being 0 the worst and 3,600 the best. Generally, all breast cancers are classified in four stages, from stage14. The aim of this study was to investigate the histologic and surgical factors associated with local recurrence.
These are rare breast tumors that start in the connective stromal tissue of the breast. Nov 15, 2019 borderline phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Phyllodes tumors are uncommon and unpredictable mayo clinic. Jan 19, 20 depending on the size of the breast and the location of the phyllodes tumor, mastectomy may also be required for tumors that are between 5 and 10 cm in diameter. The most common site of phyllodes tumor is the breast in general, phyllodes tumor may be classified as benign, malignant, or borderline tumor based on. Distant metastases in phyllodes tumours of the breast. Organization yaitu tumor phyllodes filodes sebagai penamaan yang paling sesuai. Clinical suspicion of phyllodes tumor based on clinical criteria e.
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